Zaprinast, solid

Stock Code: 2794308
Manufacturer Part No: Z0878-25MG

Order Now for 21 day delivery

Descriptions

Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

Biochem/physiol Actions

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

Packaging

25, 100 mg in poly bottle

Specifications

Colour	white
Quality Level	200
InChI key	REZGGXNDEMKIQB-UHFFFAOYSA-N
InChI	1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
Solubility	DMSO: 10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, H2O: insoluble
Form	solid