XIE62-1004

XIE62-1004

Stock Code: 3576621
Manufacturer Part No: SML2638-5MG
Order Now for 7 day delivery
£151.82 (exc VAT) per EACH
Quantity: - +

Biochem/physiol Actions


XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 µM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 µM, 18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectants, as well as in wild-type, but not autophagy defective Atg5-/- MEFs (GFP-HDQ103).

Colourwhite to beige
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityH2O: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.