X-34

X-34

Stock Code: 3575611
Manufacturer Part No: SML1954-25MG
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Biochem/physiol Actions


X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.


Fluorescent, amyloid-specific dye


X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule ?-secretase modulators (GSMs) involved in lowering A?42 levels (the 42-residue isoform of the amyloid-? peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer?s disease (AD).

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 2.0 mg/mL, clear
Formpowder
Assay≥90% (HPLC)

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