VX-745

VX-745

Stock Code: 3575194
Manufacturer Part No: SML1638-25MG
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£452.68 (exc VAT) per 25MG
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Biochem/physiol Actions


VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.


Other Notes


VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyVEPKQEUBKLEPRA-UHFFFAOYSA-N
InChI1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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