VILDAGLIPTIN

VILDAGLIPTIN

Stock Code: 3576117
Manufacturer Part No: SML2302-250MG
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£392.79 (exc VAT) per 250MG
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Application


Vildagliptin has been used:as a dipeptidyl peptidase-4 (DPP4) inhibitor to study its effects on endoplasmic reticulum (ER) pathway under diabetic conditionsin pharmacological inhibition to investigate the kinetics of transposable element (TE) desilencing and confirm its dependence on DPF-3 (a P-granule-localized N-terminal dipeptidase) enzymatic activityto study its electrochemical properties and determinationin biological fluid and drug forms


Biochem/physiol Actions


Vildagliptin ia a selective inhibitor of dipeptidyl peptidase 4 (DPP4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones that are released in response to a meal. By preventing GLP-1 and GIP inactivation, GLP-1 and GIP are able to potentiate the secretion of insulin and suppress the release of glucagon by the pancreas.


Vildagliptin may participate in lipid metabolism. It plays a key role in attenuating postprandial hypertriglyceridemia, reducing serum triglycerides, apolipoprotein B, and blood total cholesterol levels. Vildagliptin is used in diabetes mellitus type 2 (DM2) therapy and may also possess vasculoprotective properties. Vildagliptin also helps to improve mitochondrial dysfunction caused by diabetes.

Colourwhite to beige
InChI keySYOKIDBDQMKNDQ-NHMCJKAESA-N
InChI1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12-,13+,14-,16+,17-/m0/s1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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