Vasoactive Intestinal Peptide human, porcine, rat, from synthetic, >=95% (HPLC), powder

Vasoactive Intestinal Peptide human, porcine, rat, from synthetic, >=95% (HPLC), powder

Stock Code: 3593855
Manufacturer Part No: V6130-250UG
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£465.21 (exc VAT) per 250UG
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Amino Acid Sequence


His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2


Application


Vasoactive Intestinal Peptide human, porcine, rat was used to treat human donor corneoscleral explants to maintain corneal endothelial (CE) integrity during eye banking. The product was also used as a test compound for studying its impact on swimbladder blood flow by using saline- or blood-perfused swimbladder preparations of the freshwater European eel Anguilla Anguilla.


Vasoactive Intestinal Peptide human, porcine, rat has been used to study its ability to stimulate adenosine 3?,5?-cyclic monophosphate (cyclic AMP) formation in the hypothalamus and cerebral cortex of chick and rats.


Biochem/physiol Actions


Vasoactive Intestinal Peptide human, porcine, rat (VIP) is a neuropeptide synthesized in the central nervous system that enhances the formation of adenosine 3?,5?-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP modulates the cholinergic as well as serotonergic neurotransmitter systems.


Neuropeptide that is widely distributed in the central and peripheral nervous systems. It is a vasodilator, bronchodilator and smooth muscle relaxant. It modulates the activity of many immune system cell types. It is a mitogen for embryonic sympathetic neurons. Its neuroprotective actions are mediated by the release of activity-dependent neurotrophic factors from glial cells.


General description


Vasoactive Intestinal Peptide (VIP) is expressed in airway epithelial cells, secretory glands, immune and inflammatory cells. It functions as a neuroendocrine hormone and putative neurotransmitter. It stimulates neuronal survival and modulates glycogen metabolism. VIP blocks mitogen-activated proliferation of T cells by preventing interleukin-2 production. It promotes electrolyte secretion and provides protection against oxidant injury.


Other Notes


Lyophilized from 0.1% TFA in H2O


Preparation Note


Vasoactive Intestinal Peptide human, porcine, rat dissolves in distilled water and1% acetic acid to yield a clear, colorless solution.

Quality Level200
InChI keyHEOYHMUESMJFDC-RIWXPGAOSA-N
InChI1S/C147H238N44O42S/c1-18-75(12)115(143(231)182-97(56-72(6)7)131(219)174-94(118(156)206)61-108(153)199)189-140(228)106(68-193)186-135(223)102(63-110(155)201)179
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95% (HPLC)

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