Vasoactive Intestinal Peptide human, porcine, rat, >=95% (HPLC), powder

Vasoactive Intestinal Peptide human, porcine, rat, >=95% (HPLC), powder

Stock Code: 3593844
Manufacturer Part No: V3628-.5MG
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Amino Acid Sequence


His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2


Application


Vasoactive Intestinal Peptide human, porcine, rat was used as an antigen utilized in absorption purpose for systematic study of nervous system of the chicken proventriculus by using immunohistochemistry and electron microscopy.


Vasoactive Intestinal Peptide human, porcine, rat has been used as an immunogen to analyze the immunohistochemical reactions. It has also been used in cell migration assay.


Biochem/physiol Actions


VIP (Vasoactive intestinal peptide) possesses anti-inflammatory and immunomodulatory functions. It controls the pathogenesis of rheumatoid arthritis. It is also involved in neuroblastoma differentiation, and pancreatic insulin secretion. Vip exhibits its function through G-protein coupled receptors. Some of the other important actions of VIP is associated with the digestive, respiratory, cardiovascular and reproductive systems.


Vasoactive Intestinal Peptide human, porcine, rat is a neuropeptide synthesize in the central nervous system, which enhances the formation of adenosine 3?,5?-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP also modulates the cholinergic as well as serotonergic neurotransmitter systems.


Neuropeptide that is widely distributed in the central and peripheral nervous systems. It is a vasodilator, bronchodilator and smooth muscle relaxant. It modulates the activity of many immune system cell types. It is a mitogen for embryonic sympathetic neurons. Its neuroprotective actions are mediated by the release of activity-dependent neurotrophic factors from glial cells.


General description


The vasoactive intestinal peptide (VIP) gene is mapped to human chromosome 6q25.2. This gene encodes a neuropeptide containing 28-amino acid. Vip belongs to the glucagon/secretin superfamily and is conserved along evolution. It is predominantly localized to the central and peripheral nervous systems.


Packaging


0.5, 1 mg in glass bottle


250 µg in glass bottle


Preparation Note


Vasoactive Intestinal Peptide human, porcine, rat dissolves in water at 0.1% in 1% acetic acid to yield a clear, colorless solution.

Quality Level200
InChI keyHEOYHMUESMJFDC-RIWXPGAOSA-N
InChI1S/C147H238N44O42S/c1-18-75(12)115(143(231)182-97(56-72(6)7)131(219)174-94(118(156)206)61-108(153)199)189-140(228)106(68-193)186-135(223)102(63-110(155)201)179
ManufacturerSIGMA-ALDRICH
Solubility1% acetic acid: 0.1%, clear, colorless
Formpowder
Assay≥95% (HPLC)

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