Tubacin, >=98% (HPLC)

Tubacin, >=98% (HPLC)

Stock Code: 3574012
Manufacturer Part No: SML0065-5MG
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£892.82 (exc VAT) per 5MG
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Application


Tubacin was used to study the role of HDAC6 in migration and invasion of bladder cancer cells.


Biochem/physiol Actions


Tubacin is a selective inhibitor of histone deacetylase 6 (HDAC6), a predominantly cytoplasmic class II histone deacetylase that is involved in many cellular processes, including degradation of misfolded proteins, cell migration, and cell-cell interaction. Tubacin selectively inhibit HDAC6-mediated alpha -tubulin deacetylation.


Tubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


1, 5 mg in glass bottle

Colourwhite to tan
Quality Level100
InChI keyBHUZLJOUHMBZQY-YXQOSMAKSA-N
InChI1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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