TREPROSTINIL

TREPROSTINIL

Stock Code: 3575041
Manufacturer Part No: SML1531-5MG
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£288.32 (exc VAT) per 5MG
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Biochem/physiol Actions


Treprostinil is a stable synthetic analog of prostacyclin (prostaglandin PGI2), an IP receptor agonist used clinically for the treatment of pulmonary arterial hypertension. It is a potent vasodilator with antithrombotic, antiproliferative and anti-inflammatory properties.


Treprostinil elicits a longer half-life when compared with iloprost. It mediates inhibition of transforming growth factor-? (TGF-?) and nuclear factor-?B (NF-?B) signaling pathways. Treprostinil effectively reduces right ventricular systolic pressure and inhibits the recruitment of circulating fibrocyte.

Colourwhite to beige
Quality Level100
InChI keyIQKAWAUTOKVMLE-DQHZMXPSSA-M
InChI1S/C23H34O5.Na/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25;/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27);/q;+1/p-
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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