TONABERSAT

TONABERSAT

Stock Code: 3574793
Manufacturer Part No: SML1354-25MG
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£924.86 (exc VAT) per 25MG
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Biochem/physiol Actions


Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.


Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyXLIIRNOPGJTBJD-ROUUACIJSA-N
InChI1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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