TNCA

TNCA

Stock Code: 3575300
Manufacturer Part No: SML1711-50MG
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£270.21 (exc VAT) per 50MG
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Biochem/physiol Actions


TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyFSNCEEGOMTYXKY-JTQLQIEISA-N
InChI1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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