TIPIFARNIB

TIPIFARNIB

Stock Code: 3575241
Manufacturer Part No: SML1668-25MG
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£628.18 (exc VAT) per 25MG
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Biochem/physiol Actions


Tipifarnib (R115777) is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand.


General description


Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyPLHJCIYEEKOWNM-HHHXNRCGSA-N
InChI1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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