TIC10 ANGULAR

TIC10 ANGULAR

Stock Code: 3574424
Manufacturer Part No: SML1068-5MG
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£174.11 (exc VAT) per 5MG
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Biochem/physiol Actions


TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers. TIC10 angular inactivates both Akt and ERK, which results in Foxo3a nuclear factor migration to the nucleus and binding to TRAIL promoter.


TIC10 (TRAIL-inducing compound 10) induces apoptosis mediated by TRAIL (TNF-related apoptosis-inducing ligand) in a number of cancers without toxicity such as breast, colon and glioblastoma multiforme tumors.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


General description


TIC10 (TRAIL-inducing compound 10) is an anticancer molecule also referred as ONC201.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 5 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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