TH1020

TH1020

Stock Code: 3575333
Manufacturer Part No: SML1741-5MG
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£131.76 (exc VAT) per 5MG
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Application


TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.


Biochem/physiol Actions


TH1020 mediates the inhibition of tumor necrosis factor-? (TNF-?) based signaling, It disrupts tetrameric complex by binding the molecular interface between dimeric TLR5.


TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 3 mg/mL, clear (warmed)
Formpowder
Assay≥95% (HPLC)

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