TAZAROTENIC ACID

TAZAROTENIC ACID

Stock Code: 3575170
Manufacturer Part No: SML1619-5MG
Order Now for 7 day delivery
£196.39 (exc VAT) per 5MG
Quantity: - +

Biochem/physiol Actions


Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation.


Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) that binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
Quality Level100
InChI keyIQIBKLWBVJPOQO-UHFFFAOYSA-N
InChI1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.