TAKINIB

TAKINIB

Stock Code: 3575974
Manufacturer Part No: SML2216-25MG
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Application


Takinib has been used as an inhibitor of transforming 28 growth factor - ?-activated kinase -1 (TAK-1) in human leukemia monocyticTHP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.


Biochem/physiol Actions


Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer.


General description


Takinib belongs to the aminobenzimidazole class of inhibitors.

Colourwhite to beige
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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