SYROSINGOPINE

SYROSINGOPINE

Stock Code: 3575534
Manufacturer Part No: SML1908-5MG
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£150.43 (exc VAT) per 5MG
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Application


Syrosingopine has been used as a monocarboxylate transporter (MCT) inhibitorto study its effects on anti-CD147-induced metabolon disruption in human breast cancer cellsto study its effects on Cryptosporidium parvum-infected HCT-8 cellsin orthogonal linear separation analysis (OLSA)-derived decomposed analysis


Biochem/physiol Actions


Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells. Syrosingopine was also found to potentiate the anticancer activity of mitochondrial electron transport chain (ETC) inhibitors. Its mechanism of action is currently unknown but may involve inhibition of glycolytic enzyme α-enolase rather than its known activity as an inhibitor of vesicular monoamine transporters VMAT1 and VMAT2.


Syrosingopine is a derivative of reserpine and inhibits monocarboxylate lactate transporters 1 and 4 (MCT1/4).

Colourwhite to light brown
Quality Level100
InChI keyZCDNRPPFBQDQHR-SSYATKPKSA-N
InChI1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)3
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 10 mg/mL, clear
Formpowder

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