Strychnine

Strychnine

Stock Code: 3592153
Manufacturer Part No: S0532-10G
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Application

Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.

Strychnine has been used as a glycine receptors antagonist in hippocampalCA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the ? subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.

At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.

General description

Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.

Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.

Packaging

5, 10, 25, 100 g in glass bottle

Quality Level200
mp284-286 °C (lit.)
InChI keyQMGVPVSNSZLJIA-FVWCLLPLSA-N
InChI1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s
ManufacturerSIGMA-ALDRICH
Solubilitychloroform: soluble, clear to hazy

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