SQ109

SQ109

Stock Code: 3574732
Manufacturer Part No: SML1309-10MG
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£408.11 (exc VAT) per 10MG
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Application


SQ109 has been used: as an antitubercularagent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis(Mtb) using the resazurin microtiter assay (REMA) plate method as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action


Biochem/physiol Actions


SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.


SQ109 is an antitubercular developed for the treatment of multidrug-resistant tuberculosis (MDR-TB). SQ109 inhibits the activity of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.


General description


SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.

Colourcolorless to yellow
Quality Level100
InChI keyJFIBVDBTCDTBRH-REZTVBANSA-N
InChI1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formoil
Assay≥98% (HPLC)

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