SPP86

SPP86

Stock Code: 3574904
Manufacturer Part No: SML1435-25MG
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£454.07 (exc VAT) per 25MG
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Biochem/physiol Actions


SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 µM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 µM, similar to tamoxifen.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyJQOIRTDBHMDWMT-UHFFFAOYSA-N
InChI1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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