Spermine tetrahydrochloride, BioReagent, for molecular biology

Spermine tetrahydrochloride, BioReagent, for molecular biology

Stock Code: 3582132
Manufacturer Part No: S1141-1G
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Application


Used to precipitate DNA from low salt aqueous buffers.


Biochem/physiol Actions


Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).


Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).


General description


Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Quality Level300
mp310-311 °C (dec.) (lit.)
InChI keyXLDKUDAXZWHPFH-UHFFFAOYSA-N
InChI1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
ManufacturerSIGMA-ALDRICH
Product LineBioReagent
Formsolid

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