SID 3712249

SID 3712249

Stock Code: 3575019
Manufacturer Part No: SML1518-25MG
Order Now for 7 day delivery
£373.29 (exc VAT) per 25MG
Quantity: - +

Biochem/physiol Actions


SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.


Other Notes


light sensitive


Packaging


5, 25 mg in glass bottle

Colourwhite to brown
Quality Level100
InChI keySSWVPYMSHHEYAB-UHFFFAOYSA-N
InChI1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 15 mg/mL, clear
Formpowder
Assay≥95% (HPLC)

There are no downloads for this product.