SB-408124, >=98% (HPLC), solid

SB-408124, >=98% (HPLC), solid

Stock Code: 3573897
Manufacturer Part No: S2694-25MG
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£629.57 (exc VAT) per 25MG
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Application


SB-408124 was used to block orexin A-mediated cardiovascular effects in rats. It was used to study block the increase of endogenous glucose production mediated by bicuculline in rats.


Biochem/physiol Actions


SB-408124 blocks the orexin type 1 receptor that stimulates the production of stress hormone in hypothalamus. It blocks orexin A-induced increase in arterial pressure and elevation of heart rate in rats. SB-408124 modulates phrenic nerve activity that is important in respiration.


SB 408124 is an OX1 orexin receptor antagonist.


Features and Benefits


This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Legal Information


Sold for research purposes under agreement from GlaxoSmithKline


Packaging


5, 25 mg in glass bottle

Colouroff-white
Quality Level100
InChI keyJTARFZSNUAGHRB-UHFFFAOYSA-N
InChI1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)
ManufacturerSIGMA-ALDRICH
Formsolid
Assay≥98% (HPLC)

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