SANT-1, >=98% (HPLC), powder

SANT-1, >=98% (HPLC), powder

Stock Code: 3573910
Manufacturer Part No: S4572-25MG
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£951.32 (exc VAT) per 25MG
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Application


Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.


Biochem/physiol Actions


SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.


SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-?B pathway in glioblastoma cells.


Packaging


5, 25 mg in glass bottle

Quality Level100
InChI keyFOORCIAZMIWALX-JJIBRWJFSA-N
InChI1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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