S1QEL1.1

S1QEL1.1

Stock Code: 3575601
Manufacturer Part No: SML1948-5MG
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£168.54 (exc VAT) per 5MG
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Application


S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor: to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection in combination with mito-antioxidant to study their influence on mitochondria-derived H2O2 in cancer cells to determine the effect of oxidative stress depletion on myoblast differentiation


Biochem/physiol Actions


Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).


S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H2O2 production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H2O2 production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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