RU.521

RU.521

Stock Code: 3576179
Manufacturer Part No: SML2347-5MG
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£196.39 (exc VAT) per 5MG
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Biochem/physiol Actions


RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that suppresses the chronically elevated levels of type I interferon in primary macrophages from Trex1 null mice. Ru.521 binds to the CGAS catalytic pocket and inhibits dsDNA-induced cGAS-mediated interferon upregulation.


RU.521 helps to understand the biological functions of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) synthase. It can act as a molecular scaffold for developing future autoimmune therapies. RU.521 can also inhibit the inflammatory cytokine expression induced by Aspergillus fumigatus.

Colourwhite to beige
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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