RO8191 is an orally available, potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2). RO8191 suppresses HCV replication without inducing host cell toxicity.
RO8191 is an imidazonaphthyridinecompound, which activates interferon(IFN) signals, IFN-stimulated genes (ISGs) expression and Janus kinase (JAK)/signal transducers and activators of transcription (STAT) phosphorylation.