RN-9893

RN-9893

Stock Code: 3575065
Manufacturer Part No: SML1547-25MG
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£388.61 (exc VAT) per 25MG
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Biochem/physiol Actions


RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC50 values of 420 nM, 660 nM, and 320 nM for human, rat and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 µM, an IC50 >30 µM against TRPV3, an IC50 of approximately 30 µM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.


General description


RN-9893 is a small, orally bioavailable antagonist of TRPV4 (transient receptor potential subfamily V4. It is a tri-substituted benzamide compound.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyKORKKQLDGMHNKO-UHFFFAOYSA-N
InChI1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 25 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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