RI(DL)-2

RI(DL)-2

Stock Code: 3575455
Manufacturer Part No: SML1851-25MG
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£435.96 (exc VAT) per 25MG
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Biochem/physiol Actions


RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 µM) without affecting its ssDNA-binding activity (IC50 >100 µM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 µM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.


Packaging


5, 25 mg in glass bottle

Colour, light orange to dark red
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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