RGFP966

RGFP966

Stock Code: 3575219
Manufacturer Part No: SML1652-25MG
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£566.89 (exc VAT) per 25MG
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Biochem/physiol Actions


RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 80 nM and no inhibition of any other HDACs at concentrations up to 15 µM. In mouse studies, RGFP966 facilitated extinction of cocaine-seeking behavior and enhanced long-term object memory acquisition and consolidation. In a rat study, RGFP966 ameliorated amyloid-β oligomer-induced synaptic plasticity impairment. RGFP966 was also found to reduce proliferation and inducd differentiation in mouse lymphoid and myeloid malignancies.


RGFP966 changes signal-specific primary auditory cortical plasticity. It is highly effective in cardiomyopathy-associated pathologies.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyBLVQHYHDYFTPDV-VCABWLAWSA-N
InChI1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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