RA-9

RA-9

Stock Code: 3574597
Manufacturer Part No: SML1206-25MG
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£533.46 (exc VAT) per 25MG
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Biochem/physiol Actions


RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyYUYPWAMLWZVHAE-KAVGSWPWSA-N
InChI1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 2 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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