Picropodophyllotoxin, >=96% (HPLC), powder

Picropodophyllotoxin, >=96% (HPLC), powder

Stock Code: 3576983
Manufacturer Part No: T9576-5MG
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£686.68 (exc VAT) per 5MG
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Biochem/physiol Actions


Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable.


Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.


Features and Benefits


This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


1, 5 mg in glass bottle


Preparation Note


Picropodophyllotoxin is soluble in DMSO at a concentration that is greater than 5 mg/ml.


Quality


May contain 2-3% ethanol (w/w)

Colourwhite
Quality Level100
InChI keyYJGVMLPVUAXIQN-HAEOHBJNSA-N
InChI1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥96% (HPLC)

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