Phloretin, >=99%

Phloretin, >=99%

Stock Code: 3577884
Manufacturer Part No: P7912-100MG
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£207.54 (exc VAT) per 100MG
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Application


Phloretin has been used:to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptaketo incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assayas a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro


Biochem/physiol Actions


Blocks L-type Ca2+ channels; activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.


Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.


Phloretin is known to decrease interfacial dipole potential of lipid bilayer. Phloretin possess antitumor action by preventing protein kinase C (PKC) activity and stimulating programmed cell death. It is found to inhibit the transport functions of GLUTs (glucose transporter) and aquaporins.


General description


Major polyphenol found in apple; aglycone of phloridzin.


Phloretin a polar dye belongs to the class of dihydrochalcones.


Packaging


25, 100, 250 mg in poly bottle

Quality Level200
mp~260 °C
InChI keyVGEREEWJJVICBM-UHFFFAOYSA-N
InChI1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formpowder
Assay≥99%

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