PF-6274484

PF-6274484

Stock Code: 3573787
Manufacturer Part No: PZ0342-5MG
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£124.94 (exc VAT) per 5MG
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Biochem/physiol Actions


PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Other Notes


This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
Quality Level100
InChI keyDTMQCGFVWWBONL-UHFFFAOYSA-N
InChI1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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