PF-06928215

PF-06928215

Stock Code: 3573849
Manufacturer Part No: PZ038-25MG
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£490.29 (exc VAT) per 25MG
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Application


PF-06928215 has been used to study its inhibitory effects on cyclic GMP-AMP synthase (cGAS).


Biochem/physiol Actions


PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 µM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed.


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.

Colourwhite to beige
ManufacturerSIGMA-ALDRICH
Storage Temp.room temp
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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