PF-06424439

PF-06424439

Stock Code: 3573629
Manufacturer Part No: PZ0233-25MG
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£551.57 (exc VAT) per 25MG
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Application


PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)inhibitor:to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cellsto study its effects on HeLa cellsto study its inhibitory effects on neutral lipid synthesis in HT-1080 cells


Biochem/physiol Actions


PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.


PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Other Notes


This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
InChI keyZSTFDNQQOJUJFL-XFULWGLBSA-N
InChI1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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