PF-05212384 98% (HPLC)

PF-05212384 98% (HPLC)

Stock Code: 3573690
Manufacturer Part No: PZ0281-25MG
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£424.82 (exc VAT) per 25MG
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Biochem/physiol Actions


PF-05212384, also known as PKI-587 and Gedatolisib, is a dual phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) inhibitor. PKI-587 potently inhibited class I PI3Ks (IC50 vs PI3K-A = 0.4 nM), PI3K-A mutants, and mTOR. PF-05212384 inhibited growth of 50 diverse human tumor cell lines at IC50s ﹤100 nM and has been in clinical trials in patients with advanced solid tumors. PF-05212384 has also been found to sensitize cells to radiation.


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Other Notes


This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.room temp
SolubilityDMSO: 0.5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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