PF-04995274

PF-04995274

Stock Code: 3573723
Manufacturer Part No: PZ0310-25MG
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£413.68 (exc VAT) per 25MG
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Biochem/physiol Actions


PF-04995274 is a potent partial agonist of serotonin 5HT4 receptor with Ki = 0.15?- 0.46 nM for 5-HT4 isoforms a, b, d and e. 5-HT4 agonists modulate cholinergic function are being studied as possible treatment for cognitive disorders associated with Alzheimer′s Disease. PF-04995274 is brain penetrant and was shown to increase brain acetylcholine levels and reversed scopolamine-induced learning deficits in the rat Morris water maze test.


PF-04995274 favors the production of cyclic adenosine monophosphate (cAMP).


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Other Notes


This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyWLLOFQROROXOMO-GOSISDBHSA-N
InChI1S/C23H32N2O6/c26-23(7-12-27-13-8-23)16-25-9-4-17(5-10-25)14-29-22-21-19(30-18-6-11-28-15-18)2-1-3-20(21)31-24-22/h1-3,17-18,26H,4-16H2/t18-/m1/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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