PF-04447943

PF-04447943

Stock Code: 3573843
Manufacturer Part No: PZ0380-25MG
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£474.96 (exc VAT) per 25MG
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Biochem/physiol Actions


PF-04447943 is a potent selective brain penetrant phosphodiesterase PDE9A inhibitor both potency (8 nM) and selectivity (>10 µM versus all the PDEs except PDE1C at >1 µM). It has been investigated for the treatment of cognitive disorders including Alzheimer′s Disease. PF-04447943 increased neurite outgrowth and synapse formation in hippocampal neurons in culture, exhibited synaptic stabilization in an amyloid precursor protein (APP) transgenic mouse model, and improved memory and enhanced attention in several animal models.


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Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.

Colourwhite to beige
ManufacturerSIGMA-ALDRICH
Storage Temp.room temp
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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