OPHIOBOLIN A

OPHIOBOLIN A

Stock Code: 3574963
Manufacturer Part No: SML1478-100UG
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£118.81 (exc VAT) per 100UG
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Biochem/physiol Actions


Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.


Other Notes


Light and air sensitive.


Packaging


1 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyMWYYLZRWWNBROW-BDZRSQQBSA-N
InChI1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95% (HPLC)

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