OGG1 INHIBITOR O8

OGG1 INHIBITOR O8

Stock Code: 3575282
Manufacturer Part No: SML1697-25MG
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£502.82 (exc VAT) per 25MG
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Biochem/physiol Actions


OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.


General description


Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyHSSHUDKWJRJKPV-UHFFFAOYSA-N
InChI1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 5 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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