OGERIN

OGERIN

Stock Code: 3574968
Manufacturer Part No: SML1482-25MG
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£550.18 (exc VAT) per 25MG
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Application


Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization and phosphatidylinositol hydrolysis assay.


Biochem/physiol Actions


Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.


Packaging


5, 25 mg in glass bottle


Recommended products


Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here.

Colourwhite to beige
Quality Level100
InChI keyMDGIEDNDSFMSLP-UHFFFAOYSA-N
InChI1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 25 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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