NU6140

NU6140

Stock Code: 3574750
Manufacturer Part No: SML1323-5MG
Order Now for 7 day delivery
£167.14 (exc VAT) per 5MG
Quantity: - +

Application


NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripotency of human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells.


Biochem/physiol Actions


NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.


NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyXHEQSRJCJTWWAH-UHFFFAOYSA-N
InChI1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.