NHI-2

NHI-2

Stock Code: 3574945
Manufacturer Part No: SML1463-5MG
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£167.14 (exc VAT) per 5MG
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Biochem/physiol Actions


NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). NHI-2 has anti-glycolytic activity against a variety of cancer cells. NHI-2 inhibited cell growth of pancreatic cancer LPC006 and PANC-1 cells and enhanced the antiproliferative effects of Gemcitabine and caused apoptosis in colon cancer HCT116 cells.


NHI-2 possesses highr cell permeability.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyYPPFWRWCZNXINO-UHFFFAOYSA-N
InChI1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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