NEOSEPTIN-3

NEOSEPTIN-3

Stock Code: 3575266
Manufacturer Part No: SML1686-25MG
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£462.43 (exc VAT) per 25MG
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Biochem/physiol Actions


Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). This activated mTLR4/ mTLR promotes canonical myeloid differentiation primary response gene 88 (MyD88) and toll-interleukin(IL) 1 receptor (TIR) domain-containing adaptor inducing interferon (IFN)-? (TRIF)-dependent signaling. In addition, neoseptin-3 also stimulates tumor necrosis factor ? (TNF-?), IL-6 and IFN? production in a dose-dependent manner.


Neoseptin-3 is a highly efficacious and specific agonist of the mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (MD-2) complex. Neoseptin-3 binds to MD2, changes the conformation of MD-2 and facilitates active TLR4/MD-2 dimer formation. Neoseptin-3 exhibits no structural similarity to lipid A.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 15 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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