MSAB

MSAB

Stock Code: 3575315
Manufacturer Part No: SML1726-25MG
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£536.25 (exc VAT) per 25MG
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Biochem/physiol Actions


A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 µM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 ﹤6 µM), while exhibiting little efficacy in Wnt-independent cultures (﹤10% inhibition at 10 µM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.


Packaging


5, 25 mg in glass bottle

Colouroff-white to purple
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 25 mg/mL, clear
Formpowder
Assay≥95% (HPLC)

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