MPS1-IN-3

MPS1-IN-3

Stock Code: 3574219
Manufacturer Part No: SML0898-5MG
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£174.11 (exc VAT) per 5MG
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Application


Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.


Biochem/physiol Actions


Mps1 mediates phosphorylation of kinetochore scaffold 1.


Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 µM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.


General description


Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.


Packaging


5, 25 mg in glass bottle

Colourlight yellow to dark yellow
Quality Level100
InChI keyOFRMASLPWOMYHN-UHFFFAOYSA-N
InChI1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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