MONOCLONAL PAX-2 (EP235)

MONOCLONAL PAX-2 (EP235)

Stock Code: 3572967
Manufacturer Part No: 311R-14
Order Now for 7 day delivery
£286.05 (exc VAT) per EACH
Quantity: - +

General description


PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported ﹤em>in vitro﹤/em> with transformation of cell cultures and?﹤em>in vivo﹤/em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1 Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2 More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from?breast carcinoma (anti-PAX-2 negative).3


Legal Information


Cell Marque is a trademark of Sigma-Aldrich Co. LLC


Linkage


PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).


Other Notes


For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com


Physical form


Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.


Preparation Note


Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.


Quality


IVDIVDIVDRUO

Quality Level100; 500
ManufacturerSIGMA-ALDRICH
Further Info(For In Vitro Diagnostic Use in Select Regions (See Chart))
Storage Temp.2-8°C
Formbuffered aqueous solution

There are no downloads for this product.