MONOCLONAL IGD (EP173)

MONOCLONAL IGD (EP173)

Stock Code: 3572948
Manufacturer Part No: 268R-14
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General description


The monoclonal antibody against IgD reacts with immunoglobin D delta chains. In tonsil and lymph node, immunohistochemical staining for IgD immunoglobulin heavy chain is usually used to highlight the tonsil and nodal architecture since the IgD antibody stains mantle zone cells in secondary follicles and mantle cells in primary follicles.1 It has been reported that IgD can be detected in the surface/cytoplasm of neoplastic cells of common small B lymphoid cell lymphomas, such as small lymphocytic lymphoma, mantle cell lymphoma, marginal zone lymphoma (especially splenic marginal zone lymphoma), and follicular lymphoma.1-2 IgD expression in L & P cells of nodular lymphocyte predominant Hodkin lymphoma has been seen in subsets of cases (27% to 71.4%).1-3 The IgD positive L & P cells are usually located in the extrafollicular area with a relatively T-cell-rich background1,3 IgD expression is rarely seen in T-cell rich B-cell lymphoma. Studies have demonstrated that Reed-Sternberg cells of classic Hodgkin lymphoma were negative for IgD1,3 IgD multiple myeloma is a rare bone marrow plasma cell dyscrasia and can be identified by the IgD antibody, especially when a dry tap is encountered.4


Legal Information


Cell Marque is a trademark of Sigma-Aldrich Co. LLC


Linkage


IgD Positive Control Slides, Product No. 268S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).


Other Notes


For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com


Physical form


Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.


Preparation Note


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Quality


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Quality Level100; 500
ManufacturerSIGMA-ALDRICH
Further Info(For In Vitro Diagnostic Use in Select Regions (See Chart))
Storage Temp.2-8°C
Formbuffered aqueous solution

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