MLS000389544, >=98% (HPLC)

MLS000389544, >=98% (HPLC)

Stock Code: 3574028
Manufacturer Part No: SML0290-5MG
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£182.46 (exc VAT) per 5MG
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Biochem/physiol Actions


MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2). It effectively block TR-mediated gene transcription. MLS000389544 is selective for TR over other NR family members. It appears to act by irreversible mechanisms and target cysteine residues in the coactivator binding pocket.


Features and Benefits


This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyBTXTVUJWNPMQBT-UHFFFAOYSA-N
InChI1S/C20H24N2O7S/c1-30(27,28)17-3-2-15(7-16(17)22(25)26)19(24)29-11-18(23)21-20-8-12-4-13(9-20)6-14(5-12)10-20/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,23)
ManufacturerSIGMA-ALDRICH
SolubilityH2O: ≥5 mg/mL (warmed)
Formpowder
Assay≥98% (HPLC)

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